Robert Babak Faryabi, PhD

The overarching goal of my laboratory is to advance the mechanistic understanding of human cancer genome regulation and folding. Nearly half of all the cancer-related mutations directly and/or indirectly affect transcription factors. There is an unmet need to understand how oncogenic subversion of transcription factors regulate activity of folding of cancer genomes. To pursue this objective, we use cutting-edge chromatin conformation capture, high-content Oligopaint DNA FISH, single-cell epigenomics, functional genomics, and combine these technologies with our expertise in computational sciences to define the cause-and-effect relationship between transcriptional regulators, chromatin organization, and gene expression in cancer with the aim of advancing cancer therapy by targeting transcriptional dependencies revealed from these mechanistic studies.